About | Biomotif

Biomotif is a Swedish innovative Life Science company, focused on disruptive translational technologies.

The company develops new front-end instrumentation for mass spectrometry.

Its main objectiveis to simplify methods and instrumentation by integrating novel technology with next generation mass spectrometer systems.

Biomotif has developed the proprietary pI Trap åcelus™ for advanced proteomics and biomarker studies. The technology is based on several new inventions including ElectroCapture.

Biomotif has granted patents (IPR; No. US 7,731,827 & US 8,237,117 ) on ElectroCapture technology.

Biomotif has also filed a PCT application for the more complex pI Fractionator technology.

Thorleif Lavold - CEO

Thorleif Lavold is a businessman and entrepreneur with focus on mass spectrometry and life science applications.

In addition to Biomotif AB (2005), he has started Zula Diagnostics AB (2012) and HDXperts AB (2014).

Thorleif has more than 25 years of experience in the sales, marketing and launching of new mass spectrometers, and a successful background in multiple instrumentation companies: VG Instruments Ltd., Fisons Plc, Micromass AB (CEO) and Waters AB (Business Development).

He was Sales and Managing Director in Micromass, where he sold the two first Q-Tof hybrid mass spectrometers in the world to Astra Zeneca and Pharmacia.

In 2005, Thorleif founded Biomotif, and two patents were purchased related to the ElectroCapture technology.

Biomotif holds patents in the field of ElectroCapture, H/D Exchange MS (licensed to HDXperts AB) and pI Trap technology.

In 2014 Thorleif started HDXperts, a CRO offering Fee for service for molecular interactions and Epitope Mapping.

Dr. Juan Astorga Wells - Scientific manager

Dr. J.A.Wells is a Pharmacist and holds a PhD in Medical Biochemistry.

He has extensive experience in instrument building and testing, with special knowledge of in the combination of capillary isoelectric focusing, capillary electrophoresis and membrane-based capillary electrophoresis with mass spectrometry for the analysis of proteins and peptides. Juan is co-author on 24 peer-reviewed publications related to protein analysis by mass spectrometry

Mårten Wanning - CFO

Gia Wanning - Administration

Publications:

A membrane cell for on-line hydrogen/deuterium exchange to study protein folding and protein-protein interactions by mass spectrometry, Juan Astorga-Wells1,§, Michael Landreh1,§, Jan Johansson2,3, Tomas Bergman1, Hans Jornvall1,* (2011) (MCP Papers in Press. Published on May 24, 2011 as Manuscript M110.006510)
Oligomerization and insulin interactions of proinsulin C-peptide: Threefold relationships to properties of insulin, Jörnvall, H., Lindahl, E., Astorga-Wells, J., Lind, J., Holmlund, A., Melles, E., Alvelius, G., Nerelius, C., Mäler, L. & Johansson, J. (2010) Biochem. Biophys. Res. Commun. 391, 1561-1566 (available electronic from BBRC on 24 Dec 2009, 24280).
The extracellular domain of Bri2 (ITM2B) binds the Abri peptide (1-23) and amyloid-peptide (A1-40): Implications for Bri2 effects on processing of amyloid precursor protein and A aggregation. Peng, S., Fitzén, M., Jörnvall, H. & Johansson, J. (2010) Biochem. Biophys. Res. Commun. (electronic from 24 Dec 2009, 24277).
Peptide-binding specificity of the prosurfactant protein C Brichos domain analyzed by electrospray mass spectrometry, Fitzén, M., Alvelius, G., Nordling, K., Jörnvall, H., Bergman, T. & Johansson, J. (2009) Rapid Commun. Mass Spectrom. 23, 3591-3598.
Membrane-assisted sample preparation for online ESI-MS analysis of biomolecules, Astorga-Wells, J., Whitehouse, C., and Jornvall, H. (2009). ASMS Abstract 1917. Mol Cell Proteomics 8, 14
Membrane-assisted hydrogen/deuterium exchange mass spectrometry for protein dynamics and protein/protein interaction studies Astorga-Wells, J., Fitzén, M., and Jörnvall, H. (2010). Molecular & Cellular Proteomics.
Membrane protein identifications by mass spectrometry using electrocapture-based separation as part of a two-dimensional fractionation system. Astorga-Wells J, Tryggvason S, Vollmer S, Alvelius G, Palmberg C, Jörnvall H. (2008) Anal. Biochem. 1;381(1):33-42.
Microfluidic electrocapture-assisted mass spectrometry of membrane-associated polypeptides. Shariatgorji M, Astorga-Wells J, Jornvall H, Ilag LL. Anal. Chem. 2008 Sep 15;80(18):7116-20. 2008
Membrane protein identifications by mass spectrometry using electrocapture-based separation as part of a two-dimensional fractionation system. Astorga-Wells J, Tryggvason S, Vollmer S, Alvelius G, Palmberg C, Jörnvall H. Anal. Biochem. 2008 Oct 1;381(1):33-42.
Peptide enrichment by microfluidic electrocapture for online analysis by electrospray mass spectrometry. Vollmer S, Astorga-Wells J, Alvelius G, Bergman T, Jörnvall H. Anal. Biochem.-08 Mar 1;374(1):154-62
Formation of stable stacking zones in a flow stream for sample immobilization in microfluidic systems. Astorga-Wells J, Vollmer S, Bergman T, Jörnvall H. Anal. Chem. 2007 Feb 1;79(3):1057-63.
Microfluidic electrocapture interfaced with electrospray mass spectrometry. Susanne Vollmer, Juan Astorga-Wells, Tomas Bergman and Hans Jörnvall. International Journal of Mass Spectrometry 259, 2007, 73-78.
Microfluidic electrocapture for separation of peptides. Astorga-Wells J, Vollmer S, Tryggvason S, Bergman T, Jörnvall H. Anal. Chem. 2005 Nov 15;77(22):7131-6.
Microfluidic systems and proteomics: applications of the electrocapture technology to protein and peptide analysis. Astorga-Wells J, Vollmer S, Bergman T, Jörnvall H. Anal. Biochem. 2005 Oct 1;345(1):10-7
Multistep microreactions with proteins using electrocapture technology. Astorga-Wells J, Bergman T, Jörnvall H. Anal. Chem. 2004 May 1;76(9):2425-9.
A microfluidic electrocapture device in sample preparation for protein analysis by MALDI mass spectrometry. Astorga-Wells J, Jörnvall H, Bergman T. Anal. Chem. 2003 Oct 1;75(19):5213-9.
Fluidic preconcentrator device for capillary electrophoresis of proteins. Astorga-Wells J, Swerdlow H. Anal. Chem. 2003 Oct 1;75(19):5207-12.